Biosafety Quick Links
Animals in Research (top)
Currently we do not have an approved animal facility at ANL (the definition of an animal facility is having a live animal on site longer than 12 hours). Please refer any questions to the lab Biosafety officer.
4th National Symposium on Biosafety: Working Safely with Research Animals
Animal cell cultures : Risk assessment and biosafety recommendations - Belgium Biosafety Server
Animal Facility Biosafety Self-Audit Checklist - Princeton University
Pathogen Screening of Biological Materials - Emory University Division of Animal Resources
Risks to Assess when Selecting Clean Benches and Biosafety Cabinets for Animal Research - Baker Company Acumen Newsletter, June 2000
Autoclave Safety (top)
American Industrial Hygiene Association - Laboratory Safety Incidents : Autoclaves (see photo)
Autoclave incident photo
Autoclave Procedures - Michigan State University ORCBS
UCSF Autoclave Quality Control Program - UCSF Environmental Health and Safety Biological Safety Updates
Bacterial Strains (top)
"Bugs" Index - Organisms
CDC - Division of Bacterial and Mycotic Diseases
DSMZ -Microorganisms
Biological Safety Cabinets (top)
AIHA Laboratory Safety Incidents : Biological Safety Cabinets
Primary Containment for Biohazards: Selection, Installation, and Use of Biological Safety Cabinets, 2nd edition
Selecting A Biosafety Cabinet - NuAire Guide
Yale University - Office of Environmental Health and Safety, streaming safety videos : The Effective use of a Biosafety Cabinet
Biological Toxins (top)
Safety and Health Considerations for Conducting Work with Biological Toxins
Biosafety Levels and Checklists (top)
Description of Laboratory Biosafety Levels - University of North Carolina at Chapel Hill
Evaluating Biosafety Level Three Laboratories : An In-Depth Look at the Facility, Its Operations, and Documentation
The 1,2,3's of Biosafety Levels - CDC Office of Health and Safety
Biosafety in the Laboratory - CDC Slides presentation
Biosafety Levels of Specific Microorganisms (top)
CDC - BMBL Section VII : Agent Summary Statements
Bacterial Agents
Fungal Agents
Parasitic Agents
Prions
Rickettsial Agents
Viral Agents (other than arboviruses)
Arboviruses and Related Zoonotic Viruses
American Biological Safety Association Risk Group Classification for Infectious Agents
Appendix B of NIH Guidelines - Classification of Human Etiologic Agents on the Basis of Hazard
Bloodborne Pathogens (top)
OSHA Information on Bloodborne Pathogens
OSHA Workplace Precautions against Bloodborne Pathogens
CDC MMWR, Recommendations and Reports - Updated U.S. Public Health Service Guidelines for the Management of Occupational Exposures to HBV, HCV, and HIV and Recommendations for Postexposure Prophylaxis
APPENDIX A Practice Recommendations for Health-Care Facilities Implementing the U.S.
Public Health Service Guidelines for Management of Occupational Exposures to Bloodborne Pathogens
APPENDIX B Management of Occupational Blood Exposures
APPENDIX C Basic and Expanded HIV Postexposure Prophylaxis Regimens
Center for Disease Control Viral Hepatitis and slide-show
29 CFR 1910.1030 - Occupational Exposure to Bloodborne Pathogens
Needlestick Safety and Prevention Act
Yale University - Office of Environmental Health and Safety, streaming safety videos : Cleaning up a Blood Spill
CDC-NIH Guidelines (top)
CDC Office of Health and Safety - Biosafety in Microbiological and Biomedical Laboratories and supplement / changes in text
Cell Culture (top)
HHMI Online Safety Course - Knowing How To Practice Safe Science
Sigma Aldrich - Fundamental techniques in Cell Culture ... a Laboratory Handbook
Barkley, W.E. 1979. Safety considerations in the cell culture laboratory. Methods Enzymol. 58: 6-54.
Containment Facilities (top)
Biosafety Level 3, Physical Containment, Lawrence Berkeley National Laboratories
Yale University - Office of Environmental Health and Safety, streaming safety videos : Working Safely in a BL3 Laboratory - Guidance for Service and Maintenance Employees
Disinfection (top)
ANL Decontamination and Disinfection Fact Sheet
Summary and Comparison of Liquid Disinfection - University of Virginia Biosafety Program
Antimicrobial Chemical/Registration Indexes - US Environmental Protection Agency site : Regulating Antimicrobial Pesticides
CDC Biosafety Branch - References : Inactivation of HIV
CDC Emerging Infectious Diseases, Special Issue - New Disinfection and Sterilization Methods
Electrophoresis (top)
Electrical Shock from Electrophoresis Unit - AIHA Laboratory Health and Safety Committee
Eye Protection
Laboratory Safety Incidents : Eye Exposures - AIHA Laboratory Health and Safety Committee
Safetyglasses.com
Freezing/Thawing Specimens (top)
Laboratory Incidents Involving Cryogens - AIHA Laboratory Health and Safety Committee
Cryogenic Materials - East Carolina University Office of Environmental Health and Safety
Human Subjects Issues (top)
Currently ANL does not have an Institutional Review Board. Any human subjects issues are reviewed by the IRB at University of Chicago
United States Department of Health and Human Services - Office for Human Research protections (OHRP)
Importation Permits for Etiologic Agents, Cell Lines and Live Animals (top)
For more information, please contact Jeff McGhee in ESH at (630) 252-5712 or jmcghee@anl.gov
CDC Office of Health and Safety - Etiologic Agent Import Program
United States Department of Agriculture (USDA) - Animal and Plant Health Inspection Service (APHIS)
Infectious Agents (top)
AIHA Laboratory Health and Safety Committee - Laboratory Safety Incidents : Infectious Agents
Category A Infectious Substances
CDC - Infectious Disease Information A-Z
WHO - Infectious Diseases
Lessons Learned (top)
Lawrence Livermore National Laboratory
Microwave Safety (top)
MIT Safety Stories - The Big Blow of 99
NIH Safety Notes - Operating Microwave Ovens in the Laboratory
Material Safety Data Sheets for Infectious Substances (top)
MSDSs: ANL-East Chemical Management System
Public Health Agency of Canada - Material Safety Data Sheets for Infectious Substances
Organizations (top)
American Biological Safety Association
Canadian Infectious Disease Society
Centers For Disease Control and Prevention
Dept of Energy Biosafety
Emergency Management Issues Special Interest Group
Biosafety Working Group
Biosafety Information
National Science Advisory Board for Biosecurity
NIH - Office of Biotechnology Activities
University of Chicago - Institutional Biosafety Committee (IBC)
World Health Organization - Laboratory Biosafety Manual (PDF)
International Agencies
EBSA - European BioSafety Association
Health Protection Agency - United Kingdom Public Health
Institut de Veille Sanitaire - France (click on English version)
International Veterinary Biosafety Workgroup
Public Health Agency of Canada - Office of Laboratory Security
Prions (top)
CDC Dept of Health and Human Services - About Prion Diseases
Statement of the Swiss Expert Committee for Biosafety on BSE Diagnostics: Classification and Safety Measures
PNAS (2000) - New studies on the heat resistance of hamster-adapted scrapie agent: Threshold survival after ashing at 600°C suggests an inorganic template of replication
Advisory Committee on Dangerous Pathogens, Spongiform Encephalopathy Advisory Committee - Transmissible Spongiform Encephalopathy Agents: Safe Working and the Prevention of Infection
World Health Organization - Bovine spongiform encephalopathy (BSE)
World Health Organization - Variant Creutzfeldt-Jakob disease
World Health Organization - Disease Outbreak News
Program Content Examples (top)
Argonne National Laboratory - Environment, Safety, and Health Manual :Biosafety
Johns Hopkins University - Biosafety Manual (Section V)
Princeton University - Laboratory Biosafety Self-Audit Checklist
Yale University Office of Environmental Health and Safety - Biological Safety Manual
Recombinant DNA Guidelines (top)
NIH Guidelines, Recombinant DNA and Gene Transfer - Guidelines for Research Involving Recombinant DNA Molecules
NIH Dept of Health and Human Services, Office of Biotechnology Activities - Recombinant DNA Research: Actions Under the NIH Guidelines
NIH Office of Biotechnology Activities - Institutional Biosafety Committees FAQs of Interest to IBCs
Regulated Medical Waste (top)
Please direct any questions regarding Regulated Medical Waste to John Herman of ANL Waste Management (jherman@anl.gov)
Medical waste is:
- Any solid waste generated in the diagnosis, treatment, or immunization of human beings or animals, in research pertaining thereto, or in the production or testing of biologicals, excluding hazardous waste identified or listed under 40 CFR Part 261 or any household waste as defined in 40 CFR Sub-section 261.4 (b)(1).
www.epa.gov/OCEPAterms/mterms.html
- infectious agents such as human pathological wastes, human blood and blood products, used or unused sharps (syringes, needles, and blades), certain animal waste, and certain isolation waste.
www.co.san-bernardino.ca.us/wsd/Glossary.htm
CDC - Laboratory Waste Disposal Guide
Cornell University - Management of Regulated Medical Waste
Rutgers University - Policy for the Disposal of Biological Waste
Select Agents (top)
American Biological Safety Association - Comments on CDC Select Agent Rule
APHIS USDA - Agricultural Select Agent Program
CDC - Select Agent Program
HHS and USDA Select Agents and Toxins
Howard Hughes Medical Institute - Letter of Comments on Select Agent Rule
Office of Environmental Health and Radiation Safety (EHRS) - Destruction of Select Agents Procedures
Shipping of Specimens/IATA (top)
For more information, please contact Jeff McGhee in ESH at (630) 252-5712 or jmcghee@anl.gov
ANL Shipping and Using Materials/Samples (summary)
CDC - Packaging, Labeling and Shipping Infectious Substances
CDC - Interstate Transport of Infectious Agents
CDC - Interstate Shipment of Etiologic Agents
Cornell University, Biological Safety - Shipment of Biological and Infectious Material
Exakt-Pak - Regulatory Notes : Packaging Regulation Guidelines
FedEx Service Info - Dangerous Goods Shipping
IATA (International Air Transport Association) Shipping Information
Inmark, Inc - special container and packaging needs
Saf-T-Pak - CD coures of transporting infectious and biological specimens
Univeristy of New Hampshire (UNH), Office of Environmental Health and Safety
UNH Shipping Hazardous Materials
UNH Shipment of Biological Materials Manual
UNH Guide to Shipping With Dry Ice
UNH Shipment of Hazardous Materials Manual
UNH Classification Guide for Diagnostic Specimens and Infectious Substances
UNH The U.S. DOT Small Quantity Exceptions 49 CFR §173.4 -
UNH Shipment of Biolgical Materials and Dry Ice Manual
USDA - Import/Export of Animal Pathogens
USDA - Safeguarding Animal Health, including permits for interstate domestic transport
USDA - Plant Protection and Quarantine
World Health Organization - Guidelines for the Safe Transport of Infectious Substances and Diagnostic Specimens
Training (top)
Appropriate training for Argonne personnel is based upon JHQ responses. Your division rep will contact to you in regards to which courses are required for your position. Some additional web-based training can be seen below.
UMDNJ - Bloodborne Pathogens/Biosafety Training Module
Princeton University - Live Virus Worker Web Training
University of Wisconsin, Milwaukee - Bloodborne Pathogens Training
Oklahoma State University EHS Training - Bloodborne Pathogens
University of Wisconsin, Madison - Bloodborne Pathogens Reference and Training Manual
Howard Hughes Medical Institute - Practicing Safe Science
Madison Area Technical College Biotechnology Laboratory Technician Program - Aerosols: A Laboratory Exercise
Transilluminator (top)
AIHA Laboratory Safety Incidents : Ultraviolet Burns
Vacuum Lines Protection (top)
UCSF Environmental Health and Safety Biological Safety Update - Protection of Biosafety Cabinet (Tissue Culture Hood) Vacuum Lines
Virus-Specific Information (top)
Adenovirus
CDC Respiratory and Enteric Viruses Branch - Adenoviruses
Invitrogen - ViraPower™ Adenoviral Expression System
Dengue
CDC - Dengue Fact Sheet
WHO Health Topics - Dengue
HBC
CDC - Viral Hepatitis B FAQs
HBV MSDS - Public Health Agency of Canada
HCV
CDC - Viral Hepatitis C Fact Sheet
HCV MSDS - Public Health Agency of Canada
WHO Media Centre - Hepatitis C
HIV
CDC - Division of HIV/AIDS Prevention Fact Sheets
HIV MSDS - Public Health Agency of Canada
WHO - HIV Infections
Lentivirus
Invitrogen - CellSensor™ Lentiviral Vectors User Guide
University of Nottingham - Lentiviruses Basics
Rhinovirus
Rhinovirus MSDS - Public Health Agency of Canada
SARS
CDC Laboratory Biosafety Guidelines for Handling and Processing Specimens Associated with SARS CoV
CDC - SARS Information and Topics
WHO Communicable Disease Surveillance & Response - SARS
WHO - Summary of the Discussion and Recommendations of the SARS Laboratory Workshop, 22 Oct 2003
CDC - SARS Packing Diagnostic Specimens for Transport: Summary Instructions
West-Nile Virus
CDC - Epidemic/Epizootic West Nile Virus in the United States: Guidelines for Surveillance, Prevention and Control
CDC MMWR Weekly - Laboratory-Acquired West Nile Infections United Sates, 2002
West NIle Virus MSDS - Public Health Agency of Canada
|
